Translocation of bioactive peptides across cell membranes by carbon nanotubes

被引：852

作者：

Pantarotto, D

Briand, JP

Prato, M ^{[1
]}

Bianco, A

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] CNRS, UPR9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 01期

关键词：

D O I：

10.1039/b311254c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functionalised carbon nanotubes are able to cross the cell membrane and to accumulate in the cytoplasm or reach the nucleus without being toxic for the cell up to 10 muM.

引用

页码：16 / 17

页数：2

共 29 条

[11]

Herzenberg LA, 2002, CLIN CHEM, V48, P1819

[12] Solubilization of single-wall carbon nanotubes by supramolecular encapsulation of helical amylose [J].

Kim, OK ;

Je, JT ;

Baldwin, JW ;

Kooi, S ;

Pehrsson, PE ;

Buckley, LJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (15) :4426-4427

[13] Nonclassical transport proteins and peptides: An alternative to classical macromolecule delivery systems [J].

Kueltzo, LA ;

Middaugh, CR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (09) :1754-1772

[14] Cell-penetrating peptides [J].

Lindgren, M ;

Hallbrink, M ;

Prochiantz, A ;

Langel, U .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (03) :99-103

[15] A peptide carrier for the delivery of biologically active proteins into mammalian cells [J].

Morris, MC ;

Depollier, J ;

Mery, J ;

Heitz, F ;

Divita, G .

NATURE BIOTECHNOLOGY, 2001, 19 (12) :1173-1176

[16] Chemistry of single-walled carbon nanotubes [J].

Niyogi, S ;

Hamon, MA ;

Hu, H ;

Zhao, B ;

Bhowmik, P ;

Sen, R ;

Itkis, ME ;

Haddon, RC .

ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (12) :1105-1113

[17] Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses [J].

Pantarotto, D ;

Partidos, CD ;

Hoebeke, J ;

Brown, F ;

Kramer, E ;

Briand, JP ;

Muller, S ;

Prato, M ;

Bianco, A .

CHEMISTRY & BIOLOGY, 2003, 10 (10) :961-966

[18] Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides [J].

Pantarotto, D ;

Partidos, CD ;

Graff, R ;

Hoebeke, J ;

Briand, JP ;

Prato, M ;

Bianco, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (20) :6160-6164

[19]

RASENICK MM, 1994, J BIOL CHEM, V269, P21519

[20] Micellar nanocontainers distribute to defined cytoplasmic organelles [J].

Savic, R ;

Luo, LB ;

Eisenberg, A ;

Maysinger, D .

SCIENCE, 2003, 300 (5619) :615-618

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