Effects of bFGF and TGFβ on the expression of amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina

被引：10

作者：

Chen, ST

Jen, A

Gentleman, SM

Jen, LS

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Charing Cross Hosp, Dept Neurodegenerat Disorders, London W6 8RF, England

[2] Univ London Imperial Coll Sci Technol & Med, Sch Med, Charing Cross Hosp, MRC Lab, London W6 8RF, England

[3] Natl Cheng Kung Univ, Dept Anat, Tainan 70101, Taiwan

来源：

NEUROREPORT | 1999年 / 10卷 / 03期

基金：

英国惠康基金;

关键词：

amyloid precursor protein; B-cell lymphoma protooncogene protein; basic fibroblast growth factor; immunocytochemistry; rat; retina; transforming growth factor-beta;

D O I：

10.1097/00001756-199902250-00012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGF beta). In normal control retinas, intense immunostaining of APP and Bcl-2 was observed primarily in the endfeet and proximal part of radial processes of Muller glial cells. A dose-dependent reduction in immunostaining of APP and Bcl-2 in Muller cells was observed after injection of bFGF and TGF beta. These results provide the first evidence that APP and Bcl-2 can be down-regulated by cytokines in vivo. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：509 / 512

页数：4

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