The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

被引：136

作者：

El-Moselhy, Mohamed A. ^{[1
]}

Taye, Ashraf ^{[1
]}

Sharkawi, Sara Shaaban ^{[1
]}

El-Sisi, Suzan F. I. ^{[2
]}

Ahmed, Ahmed Fahmy ^{[3
]}

机构：

[1] Menia Univ, Fac Pharm, Dept Pharmacol & Toxicol, Al Minya, Egypt

[2] NODCAR, Dept Physiol, Giza, Egypt

[3] Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 05期

关键词：

Insulin resistance; Type 2 diabetes mellitus; TNF-alpha; Free fatty acids; Curcumin; High fat diet;

D O I：

10.1016/j.fct.2011.02.004

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study was conducted to investigate the effect of curcumin, obtained from Curcuma longa, in comparison with rosiglitazone on the progression of insulin resistance and type 2 diabetes mellitus (T2DM) and the mechanisms underlying this effect. Insulin resistance and T2DM was induced in male Sprague Dawley rats by high fat diet (HFD) feeding for 60 and for 75 days representing two regimens of the study, protection and treatment. Prophylactic oral administration of curcumin (80 mg/kg), rosiglitazone (1 mg/kg), their combination, or vehicle (in control groups) was started along with HFD feeding in different groups. Treatment is achieved by oral administration of the previously mentioned agents in the last 15 days of HFD feeding after induction of insulin resistance and T2DM in rats. Curcumin showed an anti-hyperglycemic effect and improved insulin sensitivity, and this action may be attributed at least in part to its anti-inflammatory properties as evident by attenuating TNF-alpha levels in HFD fed rats, and its anti-lipolytic effect as evident by attenuating plasma free fatty acids. The curcumin effects are comparable to those of rosiglitazone, which indicate that they may act similarly. Finally we can say that, curcumin could be a beneficial adjuvant therapy in patients with T2DM. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1129 / 1140

页数：12