Down-regulation of miR-126 expression in colorectal cancer and its clinical significance

被引：76

作者：

Li, Xiang-Min ^{[1
]}

Wang, Ai-Min ^{[1
]}

Zhang, Juan ^{[1
]}

Yi, Hong ^{[2
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Emergency Dept, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China

来源：

MEDICAL ONCOLOGY | 2011年 / 28卷 / 04期

关键词：

miR-126; Colorectal cancer; Carcinogenesis; Molecular marker; MICRORNAS;

D O I：

10.1007/s12032-010-9637-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-126 in colorectal cancers are unclear. In this study, we compared the expression of miR-126 between colorectal cancer tissues and non-tumor tissues. The expression levels of miR-126 in colorectal cancer tissues were significantly lower than those in non-tumor tissues, and miR-126 overexpression inhibited the growth of colorectal cancer cells. This new information may help to clarify the molecular mechanisms involved in colorectal carcinogenesis and to indicate that miR-126 may be a novel suppressive microRNA and help to differentiate between malignant and normal colorectal tissue.

引用

页码：1054 / 1057

页数：4

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