Comparison of serum interleukin-10 (IL-10) levels between normal volunteers and patients with advanced melanoma

被引:106
作者
Nemunaitis, J
Fong, T
Shabe, P
Martineau, D
Ando, D
机构
[1] US Oncol, Dallas, TX USA
[2] Baylor Univ, Med Ctr, Dallas, TX USA
[3] RPR Gencell, Hayward, CA USA
[4] Advance Res Associates Inc, Los Altos, CA USA
[5] Cell Genesys, Foster City, CA USA
关键词
IL-10; melanoma;
D O I
10.1081/CNV-100102550
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Melanoma is an immunoresponsive mnlignancy. Interleukin-10 (IL-10) is a potent regulator of immunosuppression. The purpose of this research was to define the relationship of serum IL-10 to survival in patients with metastatic melanoma. Forty-one melanoma patients and 50 normal volunteers were analyzed. The median IL-10 level as determined by enzyme-linked immunosorbent assay (ELISA) in melanoma patients was 8.75 pg/ml compared to <3.0 pg/ml in normal volunteers (p = 0.0001). Survival of melanoma patients with an IL-10 level above 10.0 pg/ml was 365 days compared to 557 days in patients with IL-10 levels less than 10.0 pg/ml (p = 0.0259, Wilcoxon). Elevated IL-10 levels were correlated with poor survival.
引用
收藏
页码:239 / 247
页数:9
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