Mycotoxins of Aspergillus fumigatus in pure culture and in native bioaerosols from compost facilities.

被引:63
作者
Fischer, G [1 ]
Müller, T [1 ]
Ostrowski, R [1 ]
Dott, W [1 ]
机构
[1] Univ Hosp, Rhein Westfal TH Aachen, Inst Hyg & Environm Med, D-52027 Aachen, Germany
关键词
airborne fungi; secondary metabolites; mycotoxins; compost facility; Aspergillus fumigatus; trypacidin; tryptoquivaline;
D O I
10.1016/S0045-6535(98)00391-9
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposure to secondary metabolites of airborne fungi in waste handling facilities is discussed in regard to potential toxic impacts on human health. The relevance of mycotoxins has been intensely studied in connection with contamination of food and feed. Toxic secondary metabolites are expected to be present in airborne spores, but exposure to mycotoxins in bioaerosols has not been studied sufficiently. Aspergillus fumigatus is one of the most frequent species in the air of compost plants. A wide range of secondary metabolites was found in pure cultures of freshly isolated strains of A. fumigatus. Tryptoquivaline, a compound with tremorgenic properties, and trypacidin, for which no toxic properties are described, were found in native bioaerosols in a compost facility. The highly toxic metabolites gliotoxin and verruculogen were not found in the bioaerosols. (C) 1999 Elsevier Science Ltd. All rights reserved
引用
收藏
页码:1745 / 1755
页数:11
相关论文
共 15 条
[1]  
ANDERSON JG, 1994, HLTH IMPLICATIONS FU
[2]   TRYPTOQUIVALINE AND TRYPTOQUIVALONE, 2 TREMORGENIC METABOLITES OF ASPERGILLUS-CLAVATUS [J].
CLARDY, J ;
SPRINGER, JP ;
BUCHI, G ;
MATSUO, K ;
WIGHTMAN, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (03) :663-665
[3]  
FALBE J, 1997, CD ROMPP CHEMIE LEXI
[4]  
FISCHER G, 1998, MYCOSES S1, V41
[5]   MYCOTOXINS AND INTERSTITIAL LUNG-DISEASE [J].
GHIO, AJ ;
ROGGLI, VL .
CHEST, 1995, 108 (05) :1185-1186
[6]  
HAGGBLOM P, 1987, J GEN MICROBIOL, V133, P3527
[7]  
LAFONDGRELLETY J, 1978, ANN INST PASTEUR MIC, VB129, P3
[8]  
LAND CJ, 1994, HLTH IMPLICATIONS FU
[9]   DISTRIBUTION OF TRYPACIDIN IN CULTURES OF ASPERGILLUS FUMIGATUS [J].
PARKER, GF ;
JENNER, PC .
APPLIED MICROBIOLOGY, 1968, 16 (08) :1251-&
[10]  
PASANEN AL, 1994, HLTH IMPLICATIONS FU