Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging

被引:55
作者
Hara, T
Yuasa, M
机构
[1] Int Med Ctr Japan, Dept Radiol, Shinjuku Ku, Tokyo 162, Japan
[2] Japan Steel Works Ltd, Accelerator Grp, Muroran, Hokkaido 051, Japan
关键词
D O I
10.1016/S0969-8043(98)00097-9
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
(beta-Hydroxyethyl)tri([C-11]methyl)ammonium ([C-11]choline) is a tracer very effective in imaging various human tumors using positron emission tomography (PET). We have constructed a computer-controlled [C-11]choline synthetic apparatus which carries out the whole process of synthesis and product purification automatically. The setup is simple and the process quick. In 20 min, 11 GBq of [C-11]choline (chloride) is obtainable from 26 GBq of [C-11]CO2. The final product is a sterile and pyrogen-free [C-11]choline "injection". (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:531 / 533
页数:3
相关论文
共 4 条
[1]  
COMAR D, 1976, EUR J NUCL MED, V1, P11
[2]  
Hara T, 1997, J NUCL MED, V38, P842
[3]  
Hara T., 1997, Journal of Nuclear Medicine, V38, p250P
[4]   Computer-controlled synthesis of [F-18]FDG by the tetrabutylammonium method: Achievement of high yield, purity, reproducibility, reliability, and safety [J].
Yuasa, M ;
Yoshida, H ;
Hara, T .
APPLIED RADIATION AND ISOTOPES, 1997, 48 (02) :201-205