Termination of Protein Synthesis in Mammalian Mitochondria

被引：34

作者：

Chrzanowska-Lightowlers, Zofia M. A. ^{[1
]}

Pajak, Aleksandra ^{[1
]}

Lightowlers, Robert N. ^{[1
]}

机构：

[1] Newcastle Univ, Mitochondrial Res Grp, Inst Ageing & Hlth, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 40期

基金：

英国生物技术与生命科学研究理事会;

关键词：

STOP CODON RECOGNITION; RIBOSOMAL-RNA IMPORT; RELEASE FACTORS RF1; TRANSLATION TERMINATION; CRYSTAL-STRUCTURE; GENETIC-CODE; FACTOR ERF1; MESSENGER-RNA; MECHANISM; SEQUENCE;

D O I：

10.1074/jbc.R111.290585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.

引用

页码：34479 / 34485

页数：7

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