T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis

被引：36

作者：

Cohen, Robert A. ^{[1
]}

Bayliss, George ^{[1
]}

Crispin, Jose C. ^{[1
]}

Kane-Wanger, Gwen F. ^{[1
]}

Van Beek, Christine A. ^{[2
]}

Kyttaris, Vasileios C. ^{[1
]}

Avalos, Ingrid ^{[1
]}

Yu, C. Yung ^{[3
]}

Tsokos, George C. ^{[1
]}

Stillman, Isaac E. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[3] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA

来源：

CLINICAL IMMUNOLOGY | 2008年 / 128卷 / 01期

关键词：

lupus; T cells; cryoglobulins; complement;

D O I：

10.1016/j.clim.2008.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We discuss a 53-year-old woman with systemic Lupus erythematosus who presented with vasculitis, hypocomplementemia and nephritis. Although her serum complement 4 (C4) levels were zero, she had four copies of C4 gene. Renal biopsy revealed membranoproliferative glomerulonephritis and the presence of cryoglobulins, detected by electron microscopy, and significant numbers of T cells in the interstitium. Cryoglobulins were considered responsible for the complete consumption of C4 in the serum the levels of which improved gradually after treatment. T cells in the kidney were found to express CD44 and phosphorylated ezrin/radixin/moiesin which explain why they homed to the kidney inappropriately. The contribution of cryoglobulins and T cells in the expression of kidney pathology is discussed. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 7

页数：7

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