Activation-induced deaminase: controversies and open questions

被引：46

作者：

Barreto, VM

Ramiro, AR

Nussenzweig, MC

机构：

[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10021 USA

[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.it.2004.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation-induced deaminase (AID) is required for three distinct reactions crucial to the diversification of the antibody repertoire; these are somatic hypermutation (SHM), class switch recombination (CSR) and gene conversion (GC). AID is a cytidine deaminase and is believed to initiate these reactions by dearninating cytidine residues in single-stranded DNA in Ig genes. This reaction has the potential to produce DNA damage in non-Ig genes and to destabilize the genome. Here, we review the current understanding of how AID is targeted and mutates Ig genes and how genome integrity is maintained during SHM, CSR and GC.

引用

页码：90 / 96

页数：7

共 90 条

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