Latent Mycobacterium tuberculosis -: persistence, patience, and winning by waiting

被引：231

作者：

Manabe, YC ^{[1
]}

Bishai, WR

机构：

[1] Johns Hopkins Univ, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Int Hlth, Baltimore, MD 21205 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 12期

关键词：

D O I：

10.1038/82139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to succeed against tuberculosis.

引用

页码：1327 / 1329

页数：3

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