A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

被引:76
作者
Allin, SM [1 ]
Northfield, CJ
Page, MI
Slawin, AMZ
机构
[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
[2] Univ Huddersfield, Dept Chem & Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England
关键词
D O I
10.1016/S0040-4039(98)00892-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4905 / 4908
页数:4
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