Molecular genetics and Crohn's disease

被引：2

作者：

Church, JM ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Colorectal Surg, Cleveland, OH 44195 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2001年 / 81卷 / 01期

关键词：

D O I：

10.1016/S0039-6109(05)70272-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This article reviews basic molecular genetics and summarizes recent work in the genetics of Crohn's disease. Family studies are summarized, and candidate genes are described. The current state of knowledge and the implications of possible inheritance of Crohn's disease for patient are discussed.

引用

页码：31 / +

页数：10

共 43 条

[1] Crohn's disease: Concordance for site and clinical type in affected family members - Potential hereditary influences [J].

Bayless, TM ;

Tokayer, AZ ;

Polito, JM ;

Quaskey, SA ;

Mellits, ED ;

Harris, ML .

GASTROENTEROLOGY, 1996, 111 (03) :573-579

[2] Evidence for genetic heterogeneity in IBD .1. The interleukin-2 receptor antagonist in the predisposition to suffer from ulcerative colitis [J].

Bioque, G ;

Bouma, G ;

Crusius, JBA ;

Koutroubakis, I ;

Kostense, PJ ;

Meuwissen, SGM ;

Pena, AS .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1996, 8 (02) :105-110

[3] American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12 [J].

Brant, SR ;

Fu, YF ;

Fields, CT ;

Baltazar, R ;

Ravenhill, G ;

Pickles, MR ;

Rohal, PM ;

Mann, J ;

Kirschner, BS ;

Jabs, EW ;

Bayless, TM ;

Hanauer, SB ;

Cho, JH .

GASTROENTEROLOGY, 1998, 115 (05) :1056-1061

[4] Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1q, 3q, and 4q:: Evidence for epistasis between 1p and IBD1 [J].

Cho, JH ;

Nicolae, DL ;

Gold, LH ;

Fields, CT ;

LaBuda, MC ;

Rohal, PM ;

Pickles, MR ;

Qin, L ;

Fu, YF ;

Mann, JS ;

Kirschner, BS ;

Jabs, EW ;

Weber, J ;

Hanauer, SB ;

Bayless, TM ;

Brant, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7502-7507

[5]

CHURCH JM, 1996, MOL GENETICS COLOREC

[6] Clinical characteristics of Crohn's disease in 72 families [J].

Colombel, JF ;

Grandbastien, B ;

GowerRousseau, C ;

Plegat, S ;

Evrard, JP ;

Dupas, JL ;

Gendre, JP ;

Modigliani, R ;

Belaiche, J ;

Hostein, J ;

Hugot, JP ;

VanKruiningen, H ;

Cortot, A .

GASTROENTEROLOGY, 1996, 111 (03) :604-607

[7] Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16 [J].

Curran, ME ;

Lau, KF ;

Hampe, J ;

Schreiber, S ;

Bridger, S ;

Macpherson, AJS ;

Cardon, LR ;

Sakul, H ;

Harris, TJR ;

Stokkers, P ;

Van Deventer, SJH ;

Mirza, M ;

Raedler, A ;

Kruis, W ;

Meckler, U ;

Theuer, D ;

Herrmann, T ;

Gionchetti, P ;

Lee, J ;

Mathew, C ;

Lennard-Jones, J .

GASTROENTEROLOGY, 1998, 115 (05) :1066-1071

[8] Association of HLA class II genes with susceptibility to Crohn's disease [J].

Danze, PM ;

Colombel, JF ;

Jacquot, S ;

Loste, MN ;

Heresbach, D ;

Ategbo, S ;

Khamassi, S ;

Perichon, B ;

Semana, G ;

Charron, D ;

Cezard, JP .

GUT, 1996, 39 (01) :69-72

[9]

Del Gaudio A, 1999, HEPATO-GASTROENTEROL, V46, P784

[10] Linkage and association between inflammatory bowel disease and a locus on chromosome 12 [J].

Duerr, RH ;

Barmada, MM ;

Zhang, LL ;

Davis, S ;

Preston, RA ;

Chensny, LJ ;

Brown, JL ;

Ehrlich, GD ;

Weeks, DE ;

Aston, CE .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (01) :95-100

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