Guidelines for the Pharmacological Treatment of Peripheral Neuropathic Pain: Expert Panel Recommendations for the Middle East Region

被引：40

作者：

Bohlega, S. ^{[1
]}

Alsaadi, T. ^{[2
]}

Amir, A. ^{[3
]}

Hosny, H. ^{[4
]}

Karawagh, A. M. ^{[5
]}

Moulin, D. ^{[6
]}

Riachi, N. ^{[7
,8
]}

Salti, A. ^{[9
]}

Shelbaya, S. ^{[10
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Dept Neurosci MBC 76, Riyadh 11211, Saudi Arabia

[2] Sheikh Kalifa Med City, Abu Dhabi, U Arab Emirates

[3] Int Med Ctr, Jeddah, Saudi Arabia

[4] Cairo Univ, Cairo, Egypt

[5] King Abdul Aziz Med City, Jeddah, Saudi Arabia

[6] Univ Western Ontario, London, ON, Canada

[7] Rizk Hosp, Univ Med Ctr, Beirut, Lebanon

[8] Lebanese Amer Univ, Beirut, Lebanon

[9] Zayed Mil Hosp, Abu Dhabi, U Arab Emirates

[10] Ain Shams Univ, Cairo, Egypt

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2010年 / 38卷 / 02期

关键词：

ANTIDEPRESSANTS; ANTICONVULSANTS; PREGABALIN; GABAPENTIN; NORTRIPTYLINE; DESIPRAMINE; NEUROPATHIC PAIN; MIDDLE EAST; CONSENSUS; GUIDELINES; SPINAL-CORD-INJURY; LOW-BACK-PAIN; SCREENING QUESTIONNAIRE; POSTHERPETIC NEURALGIA; COST-EFFECTIVENESS; MANAGEMENT; PREGABALIN; GABAPENTIN; PREVALENCE; BURDEN;

D O I：

10.1177/147323001003800201

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Neuropathic pain (NeP) has been the focus of extensive basic and clinical research over the past 20 years. This has led to an increased understanding of underlying pathophysiological mechanisms and the development of new therapeutic agents, as well as a clearer definition of the role of established medications. To date there are no published treatment guidelines for NeP in the Middle East. A multidisciplinary panel of Middle East and international experts met to review critically and reach a consensus on how best to apply evidence-based guidelines for the treatment of NeP (mainly peripheral NeP) in the Middle East. The expert panel recommended pregabalin, gabapentin and secondary amine tricyclic antidepressants (nortriptyline and desipramine) as first-line treatments for peripheral NeP. Serotonin-norepinephrine reuptake inhibitor antidepressants, tramadol and controlled-release opioid analgesics were recommended as second-line treatments. There is a need to increase diagnostic awareness of NeP, use validated screening questionnaires and undertake more treatment research in the Middle East region.

引用

页码：295 / 317

页数：23

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