Synthesis of phenanthridones using Diels-Alder reactions of 4-substituted 2(1H)-quinolones acting as dienophiles

被引：14

作者：

Fujita, R

Watanabe, K

Yoshisuji, T

Matsuzaki, H

Harigaya, Y

Hongo, H

机构：

[1] Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088642, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 04期

关键词：

4-substituted 2(1H)-quinolone; Diels-Alder reaction; phenanthridone; MO calculation; high pressure; electron-withdrawing group;

D O I：

10.1248/cpb.49.407

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diels-Alder reactions of 2(1H)-quinolones having an electron-withdrawing group at the 4-position with 1,3-butadiene derivatives were carried out to give the phenanthridones richly functionalized under the conditions of atmospheric and high pressure. Furthermore, the reactivities of 4-substituted 2(1H)-quinolones acting as a dienophile were examined using MO calculation.

引用

页码：407 / 412

页数：6

共 30 条

[1] REACTIONS OF DIHYDROQUINOLINES AND DIHYDROISOQUINOLINES WITH ARENESULFONYL AZIDES [J].