Embryonic stem cells: protecting pluripotency from alloreactivity

被引：19

作者：

Fairchild, Paul J.

Robertson, Nathan J.

Minger, Stephen L.

Waldmann, Herman

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Kings Coll London, Stem Cell Biol Lab, Wolfson Ctr Age Related Dis, London, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.coi.2007.07.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There can be little doubt that 2006 turned out to be the annus horribilis for therapeutic cloning by somatic nuclear transfer (SNT). As the full extent of the fraud surrounding the generation of patient-specific embryonic stem (ES) cell lines became apparent, hopes began to fade for the advent of cell replacement therapies (CRT), free from the confounding issues of immune rejection. While the dust begins to settle, it is perhaps pertinent to ask whether the promise of SNT is still worth pursuing or whether alternative strategies for immune evasion might help fill the void.

引用

页码：596 / 602

页数：7

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