The host response to anthrax lethal toxin: unexpected observations

被引：20

作者：

Prince, AS ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 05期

关键词：

D O I：

10.1172/JC1200319581

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shock-like manner. A comprehensive study (see the related article beginning on page 670) of the effects of anthrax toxin in mice demonstrates that toxin-induced death is mediated not by cytokine release, as previously thought, but by hypoxia-induced liver failure. The study strongly suggests that the therapies developed for treatment of cytokine-mediated septic shock will not be appropriate for the treatment of anthrax.

引用

页码：656 / 658

页数：3

共 14 条

[1] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [J].

Abrami, L ;

Liu, SH ;

Cosson, P ;

Leppla, SH ;

van der Goot, FG .

JOURNAL OF CELL BIOLOGY, 2003, 160 (03) :321-328

[2] Identification of the cellular receptor for anthrax toxin [J].

Bradley, KA ;

Mogridge, J ;

Mourez, M ;

Collier, RJ ;

Young, JAT .

NATURE, 2001, 414 (6860) :225-229

[3] Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen [J].

Cunningham, K ;

Lacy, DB ;

Mogridge, J ;

Collier, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) :7049-7053

[4] VIRGIL ON ANTHRAX [J].

DIRCKX, JH .

AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1981, 3 (02) :191-195

[5] Anthrax [J].

Dixon, TC ;

Meselson, M ;

Guillemin, J ;

Hanna, PC .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) :815-826

[6] ON THE ROLE OF MACROPHAGES IN ANTHRAX [J].

HANNA, PC ;

ACOSTA, D ;

COLLIER, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10198-10201

[7] ANTHRAX TOXIN EDEMA FACTOR - A BACTERIAL ADENYLATE-CYCLASE THAT INCREASES CYCLIC-AMP CONCENTRATIONS IN EUKARYOTIC CELLS [J].

LEPPLA, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3162-3166

[8]

MILNE JC, 1994, J BIOL CHEM, V269, P20607

[9]

Moayeri M, 2003, J CLIN INVEST, V112, P670, DOI [10.1172/JCI17991, 10.1172/JCI200317991]

[10] Anthrax [J].

Mock, M ;

Fouet, A .

ANNUAL REVIEW OF MICROBIOLOGY, 2001, 55 :647-671

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