Endothelin regulation of vascular tonus

被引：11

作者：

Kanaide, H

机构：

[1] Faculty of Medicine, Res. institute of Angiocardiology, Kyushu University, Fukuoka, 812, 3-1-1 Maidashi, Higashi-ku

来源：

GENERAL PHARMACOLOGY | 1996年 / 27卷 / 04期

关键词：

endothelin; endothelin receptor; endothelial cells; smooth muscle cells; EDRF;

D O I：

10.1016/0306-3623(95)02093-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Following the identification of endothelin-1 (ET-1) in 1988, an increasing body of work has accumulated on this endothelium derived vasoconstrictor peptide. 2. ET-1 may regulate the regional vascular tonus. 3. ET-1 may directly act on the underlying smooth muscle to increase the force in a paracrine manner. ET-1 may also act on the endothelium to release relaxing factors in an autocrine manner. In either case, both ET(A) and ET(B) receptors may be involved.

引用

页码：559 / 563

页数：5

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