Physiologic Characterization of Type 2 Diabetes-Related Loci

被引：40

作者：

Grarup, Niels ^{[1
]}

Sparso, Thomas ^{[1
]}

Hansen, Torben ^{[1
]}

机构：

[1] Hagedorn Res Inst, DK-2820 Gentofte, Denmark

来源：

CURRENT DIABETES REPORTS | 2010年 / 10卷 / 06期

关键词：

Type; 2; diabetes; Glycemia; beta-cell function; Insulin sensitivity; Genetic epidemiology; Physiology; FASTING PLASMA-GLUCOSE; GENOME-WIDE ASSOCIATION; BETA-CELL FUNCTION; PEPTIDE-1-INDUCED INSULIN-SECRETION; POPULATION-BASED SAMPLE; ZINC TRANSPORTER ZNT8; BODY-MASS INDEX; RISK ALLELES; SUSCEPTIBILITY LOCI; BIRTH-WEIGHT;

D O I：

10.1007/s11892-010-0154-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For the past two decades, genetics has been widely explored as a tool for unraveling the pathogenesis of diabetes. Many risk alleles for type 2 diabetes and hyperglycemia have been detected in recent years through massive genome-wide association studies and evidence exists that most of these variants influence pancreatic beta-cell function. However, risk alleles in five loci seem to have a primary impact on insulin sensitivity. Investigations of more detailed physiologic phenotypes, such as the insulin response to intravenous glucose or the incretion hormones, are now emerging and give indications of more specific pathologic mechanisms for diabetes-related risk variants. Such studies have shed light on the function of some loci but also underlined the complex nature of disease mechanism. In the future, sequencing-based discovery of low-frequency variants with higher impact on intermediate diabetes-related traits is a likely scenario and identification of new pathways involved in type 2 diabetes predisposition will offer opportunities for the development of novel therapeutic and preventative approaches.

引用

页码：485 / 497

页数：13

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