Paraneoplastic pemphigus: an association with fludarabine?

被引：36

作者：

Gooptu, C

Littlewood, TJ

Frith, P

Lyon, CC

Carmichael, AJ

Oliwiecki, S

MacWhannell, A

Amagai, M

Hashimoto, T

Dean, D

Allen, J

Wojnarowska, F

机构：

[1] Oxford Radcliffe Hosp, Dept Dermatol, Oxford, England

[2] John Radcliffe Hosp, Dept Haematol, Oxford OX3 9DU, England

[3] Radcliffe Eye Hosp, Dept Ophthalmol, Oxford, England

[4] S Cleveland Hosp, Dept Dermatol, Middlesbrough, Cleveland, England

[5] New Cross Hosp, Dept Dermatol, Wolverhampton, W Midlands, England

[6] New Cross Hosp, Dept Haematol, Wolverhampton, W Midlands, England

[7] Keio Univ, Dept Dermatol, Tokyo, Japan

[8] Kurume Univ, Dept Dermatol, Fukuoka, Japan

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2001年 / 144卷 / 06期

关键词：

chronic lymphocytic leukaemia; fludarabine; paraneoplastic pemphigus;

D O I：

10.1046/j.1365-2133.2001.04244.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.

引用

页码：1255 / 1261

页数：7

共 33 条

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Amagai M, 1999, BRIT J DERMATOL, V140, P351

[2] Antibodies against desmoglein 3 (Pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice [J].