The pattern of antiganglioside antibody reactivities producing myelinated nerve conduction block in vitro

被引：24

作者：

Arasaki, K ^{[1
]}

Kusunoki, S

Kudo, N

Tamaki, M

机构：

[1] Nippon Telegraph & Tel Corp, Kanto Teishin Hosp, Dept Neurol, Tokyo 1410022, Japan

[2] Univ Tokyo, Brain Res Inst, Dept Neurol, Neurochem Lab, Tokyo 1130033, Japan

[3] Univ Tsukuba, Inst Basic Med Sci, Dept Physiol, Tsukuba, Ibaraki 3050005, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 161卷 / 02期

关键词：

anti-ganglioside antibody; GM1; GD1b; rat; conduction block; myelinated nerve fibers;

D O I：

10.1016/S0022-510X(98)00283-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the pattern of human antiganglioside antibody reactivities causing an acute conduction block in rat myelinated nerve fibers, using an in vitro preparation of the sciatic-tibial nerve. With the aid of complements, IgM antibodies reacting with the terminal disaccharide of galactose (beta 1-3)N-acetylgalactosamine produced the block. These findings may help us to understand the mechanism in which the conduction block occurs in neuropathies associated with antiganglioside antibodies. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：163 / 168

页数：6

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