Immunostimulant oxidized β-glucan conjugates

被引：38

作者：

Cross, GG

Jennings, HJ

Whitfield, DM

Penney, CL

Zacharie, B

Gagnon, L

机构：

[1] Natl Res Council Canada, Ottawa, ON K1A 0R6, Canada

[2] BioChem Pharma Inc, Laval, PQ H7V 4A7, Canada

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2001年 / 1卷 / 03期

关键词：

beta-glucan; immunostimulant; oxidation; cytotoxic T-lymphocytes; natural killer cells;

D O I：

10.1016/S1567-5769(00)00021-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta -Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many beta -Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the beta -Glucan from Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized beta -glucan and its conjugates with O-beta -alanyl-5-[6-(N, N'-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells acid macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：539 / 550

页数：12

共 42 条

[1] Synthesis and activity of dipeptides, linked to targeting ligands, as specific NK cell enhancers [J].