The amyloid-β peptide and its role in Alzheimer's disease

被引：14

作者：

Clippingdale, AB

Wade, JD

Barrow, CJ

机构：

[1] Ocean Nutr Canada, Halifax, NS B3J 1S5, Canada

[2] Univ Melbourne, Sch Chem, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3052, Australia

来源：

JOURNAL OF PEPTIDE SCIENCE | 2001年 / 7卷 / 05期

关键词：

amyloid-beta peptide; aggregation; Alzheimer's disease; amyloid; fibrilogenesis; metal ions; neurotoxicity; peptide synthesis; structural analysis; therapeutic strategies;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Amtyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of A beta synthesis, purification and structural analysis. Also discussed are proposed mechanisms for A beta -induced neurotoxicity and some recent advances in the development of A beta -related therapeutic strategies. Copyright (C) 2001 European Peptide Society and John Wiley & Sons. Ltd.

引用

页码：227 / 249

页数：23

共 228 条

[1]

Inhibitors of β-amyloid formation based on the β-secretase cleavage site [J].