Redox Control of Vascular Nitric Oxide Bioavailability

被引：32

作者：

Price, Daniel T.

Vita, Joseph A.

Keaney, John F., Jr. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 04期

关键词：

D O I：

10.1089/ars.2000.2.4-919

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NO is an important component of vascular homeostasis and abnormal NO bioactivity has been implicated in number of disease states with important public health implications. One clear mechanism of impaired NO bioactivity and vascular disease is excess vascular oxidative stress. There is now a wealth of developing data that manipulation of vascular antioxidant stress is the considerable influence of the biologic activity of endothelium-derived NO. It remains to be seen if this influence can be exploited in a manner that truly alters the course of human disease.

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页码：919 / 936

页数：18

相关论文

共 148 条

[1] THE EFFECT OF CHOLESTEROL-LOWERING AND ANTIOXIDANT THERAPY ON ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION [J].

ANDERSON, TJ ;

MEREDITH, IT ;

YEUNG, AC ;

FREI, B ;

SELWYN, AP ;

GANZ, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (08) :488-493

[2] VITAMIN-E REVERSES CHOLESTEROL-INDUCED ENDOTHELIAL DYSFUNCTION IN THE RABBIT CORONARY CIRCULATION [J].

ANDERSSON, TLG ;

MATZ, J ;

FERNS, GAA ;

ANGGARD, EE .

ATHEROSCLEROSIS, 1994, 111 (01) :39-45

[3] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[4] PATHOLOGICAL IMPLICATIONS OF NITRIC-OXIDE, SUPEROXIDE AND PEROXYNITRITE FORMATION [J].

BECKMAN, JS ;

CROW, JP .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1993, 21 (02) :330-334

[5]

BOSCOBOINIK D, 1991, J BIOL CHEM, V266, P6188

[6] TISSUE GLUTATHIONE, NUTRITION, AND OXIDATIVE STRESS [J].

BRAY, TM ;

TAYLOR, CG .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1993, 71 (09) :746-751

[7] THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE [J].

BUETTNER, GR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) :535-543

[8] Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients [J].

Cardillo, C ;

Kilcoyne, CM ;

Cannon, RO ;

Quyyumi, AA ;

Panza, JA .

HYPERTENSION, 1997, 30 (01) :57-63

[9] ANTIATHEROGENIC EFFECT OF PROBUCOL UNRELATED TO ITS HYPOCHOLESTEROLEMIC EFFECT - EVIDENCE THAT ANTIOXIDANTS INVIVO CAN SELECTIVELY INHIBIT LOW-DENSITY-LIPOPROTEIN DEGRADATION IN MACROPHAGE-RICH FATTY STREAKS AND SLOW THE PROGRESSION OF ATHEROSCLEROSIS IN THE WATANABE HERITABLE HYPERLIPIDEMIC RABBIT [J].

CAREW, TE ;

SCHWENKE, DC ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7725-7729

[10] Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia - An effect reversible with vitamin C therapy [J].

Chambers, JC ;

McGregor, A ;

Jean-Marie, J ;

Obeid, OA ;

Kooner, JS .

CIRCULATION, 1999, 99 (09) :1156-1160

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