A Selenium Analogue of Firefly D-Luciferin with Red-Shifted Bioluminescence Emission

被引：116

作者：

Conley, Nicholas R. ^{[1
]}

Dragulescu-Andrasi, Anca ^{[2
]}

Rao, Jianghong ^{[2
]}

Moerner, W. E. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Radiol, Mol Imaging Program, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 14期

关键词：

bioluminescence; chalcogens; imaging agents; luciferase; selenium; IN-VIVO; BIOLUMINOGENIC SUBSTRATE; COENZYME-A; KINETICS; GREEN; MUTANTS; OXYLUCIFERIN; INHIBITION; OXIDATION; VITRO;

D O I：

10.1002/anie.201105653

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm (see scheme) and is suitable for bioluminescence imaging studies in living subjects. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：3350 / 3353

页数：4

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