Glycosaminoglycans: key players in cancer cell biology and treatment

被引：429

作者：

Afratis, Nikos ^{[1
]}

Gialeli, Chrisostomi ^{[1
,2
]}

Nikitovic, Dragana ^{[3
]}

Tsegenidis, Theodore ^{[1
]}

Karousou, Evgenia ^{[4
]}

Theocharis, Achilleas D. ^{[1
]}

Pavao, Mauro S. ^{[5
]}

Tzanakakis, George N. ^{[3
]}

Karamanos, Nikos K. ^{[1
,2
]}

机构：

[1] Univ Patras, Dept Chem, Biochem Lab, GR-26110 Patras, Greece

[2] Inst Chem Engn & High Temp Chem Proc FORTH ICE HT, Fdn Res & Technol, Patras, Greece

[3] Univ Crete, Sch Med, Dept Histol, Iraklion, Greece

[4] Univ Insubria, Dipartimento Sci Chirurg & Morfol, Varese, Italy

[5] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Lab Bioquim & Biol Celular Glicoconjugados, Programa Glicobiol,Inst Bioquim Med, BR-21941 Rio De Janeiro, Brazil

来源：

FEBS JOURNAL | 2012年 / 279卷 / 07期

关键词：

cancer progression; chondroitin sulfate; extracellular matrix; glycosaminoglycans; heparan sulfate; hyaluronan; pharmacological targeting; HEPARAN-SULFATE PROTEOGLYCANS; FIBROBLAST-GROWTH-FACTOR; HYALURONAN SYNTHASE SUPPRESSOR; ACTIVATED PROTEIN-KINASE; CHONDROITIN-SULFATE; BREAST-CANCER; P-SELECTIN; DERMATAN SULFATE; TUMOR-GROWTH; IN-VITRO;

D O I：

10.1111/j.1742-4658.2012.08529.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosaminoglycans are natural heteropolysaccharides that are present in every mammalian tissue. They are composed of repeating disaccharide units that consist of either sulfated or non-sulfated monosaccharides. Their molecular size and the sulfation type vary depending on the tissue, and their state either as part of proteoglycan or as free chains. In this regard, glycosami-noglycans play important roles in physiological and pathological conditions. During recent years, cell biology studies have revealed that glycosaminoglycans are among the key macromolecules that affect cell properties and functions, acting directly on cell receptors or via interactions with growth factors. The accumulated knowledge regarding the altered structure of glycosaminoglycans in several diseases indicates their importance as biomarkers for disease diagnosis and progression, as well as pharmacological targets. This review summarizes how the fine structural characteristics of glycosaminoglycans, and enzymes involved in their biosynthesis and degradation, are involved in cell signaling, cell function and cancer progression. Prospects for glycosaminoglycan-based therapeutic targeting in cancer are also discussed.

引用

页码：1177 / 1197

页数：21

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