Quinolactacins A, B and C:: Novel quinolone compounds from Penicillium sp EPF-6 II.: Physico-chemical properties and structure elucidation

被引：37

作者：

Takahashi, S

Kakinuma, N

Iwai, H

Yanagisawa, T

Nagai, K

Suzuki, K

Tokunaga, T

Nakagawa, A

机构：

[1] Teikyo Univ, Dept Biosci, Utsunomiya, Tochigi 3208551, Japan

[2] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Fuchu, Tokyo 1838509, Japan

[3] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Labs, Itabashi Ku, Tokyo 1748511, Japan

[4] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Anal & Met Labs, Tsukuba, Ibaraki 3058585, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 11期

关键词：

D O I：

10.7164/antibiotics.53.1252

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three novel quinolone compounds, quinolactacins A (1), B (2) and C (3), have been found from the fermentation broth of Penicillium sp. EPF-6, a fungus isolated from the larvae of mulberry pyralid (Margaronia pyloalis Welker). The molecular formulas of 1, 2 and 3 were determined to be C16H18N2O2, C15H16N2O2 and C16H18N2O3, respectively by FAB-MS and NMR spectral analyses. The structures of these compounds have a novel quinolone skeleton with a gamma -lactam ring consisting of C12H8N2O2 as the common chromophore.

引用

页码：1252 / 1256

页数：5

共 5 条

[1] Quinolactacins A, B and C:: Novel quinolone compounds from Penicillium sp EPF-6 I.: Taxonomy, production, isolation and biological properties [J].