Structure-functions relationships of the benzodiazepine and serotonine receptors ligands

被引：6

作者：

Andronati, SA ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, AV Bogatsky Physicochem Inst, UA-270080 Odessa, Ukraine

来源：

SUPRAMOLECULAR CHEMISTRY | 2000年 / 12卷 / 02期

关键词：

GABA; benzodiazepines; serotonine; receptors; structure; conformation; affinity; properties;

D O I：

10.1080/10610270008027448

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

States of anxiety and fear are controlled in organism by GABA-ergic and serotonine- ergic systems. Concepts about the structure and functions of GABA(A) receptor channel, benzodiazepine and serotonine receptors have been considered. Structural and conformational peculiarities of ligands of these receptors determine their role (agonists, antagonists, inverse agonists, partial agonists, partial inverse agonists) at the formation of supramolecular complexes "ligand-receptor" and, as a result, pharmacological effects of ligands.

引用

页码：169 / 179

页数：11

共 36 条

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[10] [Anonymous], MED CHEM RES

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