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Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning

被引：46
作者：
Plisov, S
Tsang, M
Shi, GB
Boyle, S
Yoshino, K
Dunwoodie, SL
Dawid, IB
Shioda, T
Perantoni, AO
de Caestecker, MP
机构：
[1] Vanderbilt Univ, Div Nephrol, Sch Med, Nashville, TN 37232 USA
[2] NCI, Comparat Carcinogenesis Lab, Frederick, MD 21701 USA
[3] NICHD, Genet Mol Lab, Bethesda, MD USA
[4] St Vincents Hosp, Victor Chang Cardiac Res Inst, Dev Biol Program, Darlinghurst, NSW 2010, Australia
[5] Univ New S Wales, Dept Biotechnol & Biomol Sci, Kensington, NSW 2033, Australia
[6] Univ New S Wales, St Vincents Clin Sch, Kensington, NSW 2033, Australia
[7] Massachusetts Gen Hosp, Ctr Canc, Dept Tumor Biol, Charlestown, MA USA
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2005年 / 16卷 / 06期
关键词：
D O I：
10.1681/ASN.2004060476
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In a screen to identify factors that regulate the conversion of mesenchyme to epithelium during the early stages of nephrogenesis, it was found that the Smad4-interacting transcriptional cofactor, Cited1, is expressed in the condensed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiation into epithelia, and has the capacity to block UB branching and epithelial morphogenesis in cultured metanephroi. Cited1 represses Wnt/beta-catenin but activates Smad4-dependent transcription involved in TGF-beta and Bmp signaling. By modifying these pathways, Cited1 may coordinate cellular differentiation and survival signals that regulate nephronic patterning in the metanephros.
引用
收藏
页码：1632 / 1644
页数：13
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