Cerebrospinal Fluid in Long-Lasting Delirium Compared With Alzheimer's Dementia

被引:39
作者
Caplan, Gideon A. [1 ,2 ]
Kvelde, Tasha [1 ]
Lai, Christina
Yap, Swee L.
Lin, Cheryl
Hill, Mark A. [3 ]
机构
[1] Prince Wales Hosp, Dept Geriatr Med, Sydney, NSW 2031, Australia
[2] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia
[3] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2010年 / 65卷 / 10期
关键词
Delirium; Dementia; Lactic acid; Neuron-specific enolase; S100; proteins; NEURON-SPECIFIC ENOLASE; OXIDATIVE STRESS; MEDICAL INPATIENTS; ELDERLY-PATIENTS; BRAIN INJURY; DISEASE; ISCHEMIA; PROTEIN; GLYCOLYSIS; METABOLISM;
D O I
10.1093/gerona/glq090
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background. Delirium is a common syndrome affecting older people in hospital, whose pathophysiology is poorly understood, but sequelae of increased cognitive and functional impairment suggest neuronal loss. Methods. Cohort study comparing cerebrospinal fluid, blood, and clinical markers of delirium and neuronal cell death in 20 older hospitalized patients with delirium and 20 outpatients with Alzheimer's dementia. Results. Compared with participants with dementia, patients with delirium demonstrated higher CSF lactate (1.87 vs 1.48 mmol/L, p < .001) and protein levels (0.62 vs 0.44 g/L, p = .036) and lower levels of neuron-specific enolase (4.84 vs 8.98 ng/mL, p < .001) but no difference in S100B. The changes correlated with clinical indices and outcomes. Conclusion. Older patients with delirium experience significant metabolic disturbance in the brain, which requires further investigation.
引用
收藏
页码:1130 / 1136
页数:7
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