1H magnetic resonance spectroscopy study of thalamus in treatment resistant depressive patients

被引：15

作者：

Mu, Jun

Xie, Peng ^{[1
]}

Yang, Ze-Song

Yang, De-Lan

Lv, Fa-Jin

Luo, Tian-You

Li, Yong

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Key Lab Diagnost Med Designated Minist Educ, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, MRI Ctr, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Hematol, Chongqing 400016, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2007年 / 425卷 / 01期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance spectroscopy; treatment resistant depression; thalamus; neuroimaging;

D O I：

10.1016/j.neulet.2007.08.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Treatment-resistant depression (TRD) is a common clinical problem, and represents a considerable challenge to treatment, however, the pathogenesis of this disease is poorly understood. Thalamus is generally believed to have a role in the pathophysiology of depression. In this study, we adopted 1.5 T H-1 magnetic resonance spectroscopy (H-1 MRS) to examine possible alterations of thalamus metabolism in 20 adult TRD patients. Our results suggested there might be damage and loss of neurons, as well as membrane phospholipids associated metabolism abnormality in the TRD thalamus. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：49 / 52

页数：4

共 26 条

[1] DEPRESSION AFTER STEREOTACTIC THALAMOTOMY IN PATIENTS WITH ABNORMAL MOVEMENTS [J].

ANGELINI, L ;

NARDOCCI, N ;

BONO, R ;

BROGGI, G .

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1982, 3 (04) :301-310

[2] Regionally specific neuronal pathology in untreated patients with schizophrenia: A proton magnetic resonance spectroscopic imaging study [J].

Bertolino, A ;

Callicott, JH ;

Elman, I ;

Mattay, VS ;

Tedeschi, G ;

Frank, JA ;

Breier, A ;

Weinberger, DR .

BIOLOGICAL PSYCHIATRY, 1998, 43 (09) :641-648

[3] 1H Magnetic prefrontal resonance spectroscopy study of dorsolateral cortex in unipolar mood disorder patients [J].

Brambilla, P ;

Stanley, JA ;

Nicoletti, MA ;

Sassi, RB ;

Mallinger, AG ;

Frank, E ;

Kupfer, DJ ;

Keshavan, MS ;

Soares, JC .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2005, 138 (02) :131-139

[4] MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals [J].

Caetano, SC ;

Sassi, R ;

Brambilla, P ;

Harenski, K ;

Nicoletti, M ;

Mallinger, AG ;

Frank, E ;

Kupfer, DJ ;

Keshavan, MS ;

Soares, JC .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2001, 108 (03) :161-168

[5] SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE MULTIPLE-SCLEROSIS LESIONS [J].

DAVIE, CA ;

HAWKINS, CP ;

BARKER, GJ ;

BRENNAN, A ;

TOFTS, PS ;

MILLER, DH ;

MCDONALD, WI .

BRAIN, 1994, 117 :49-58

[6]

De Raedt R, 1997, PSYCHIAT RES-NEUROIM, V74, P159

[7] Neuronal plasticity and survival in mood disorders [J].

Duman, RS ;

Malberg, J ;

Nakagawa, S ;

D'Sa, C .

BIOLOGICAL PSYCHIATRY, 2000, 48 (08) :732-739

[8] A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle [J].

Jiménez, F ;

Velasco, F ;

Salin-Pascual, R ;

Hernández, JA ;

Velasco, M ;

Criales, JL ;

Nicolini, H .

NEUROSURGERY, 2005, 57 (03) :585-592

[9] Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy [J].

Kalra, S ;

Cashman, NR ;

Genge, A ;

Arnold, DL .

NEUROREPORT, 1998, 9 (08) :1757-1761

[10] BRAIN N-ACETYL-L-ASPARTIC ACID IN ALZHEIMERS-DISEASE - A PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY [J].

KWOONYUEN, PF ;

NEWMARK, RD ;

BUDINGER, TF ;

KAYE, JA ;

BALL, MJ ;

JAGUST, WJ .

BRAIN RESEARCH, 1994, 667 (02) :167-174

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