Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans-10,cis-12-linoleic acid

被引:52
作者
Degrace, P
Demizieux, L
Gresti, J
Chardigny, JM
Sébédio, JL
Clouet, P
机构
[1] Univ Bourgogne, UPRES Lipides & Nutr EA2422, F-21000 Dijon, France
[2] INRA, Unite Nutr Lipid, F-21034 Dijon, France
关键词
liver steatosis; conjugated linoleic acid; lipoprotein; triacylglycerol; fatty acid; low-density lipoprotein receptor;
D O I
10.1016/S0014-5793(03)00610-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Conjugated linoleic acids (CLA) have recently been recognized to reduce body fat and plasma lipids in some animals. This study demonstrated that the steatosis accompanying the fat loss induced by trans-10,cis-12-C-18:2 (CLA2) and not cis-9,trans-11-C-18:2 (CLA1) isomer in C57BL/6j mice was not due to an alteration of the liver lipoprotein production that was even increased. The 3-fold decrease in plasma triacylglycerol contents and the induction of mRNA expression of low-density lipoprotein receptors concomitantly observed in CLA2-fed mice suggested an increase in the lipoprotein clearance at the level of the liver itself. CLA1 feeding produced similar but attenuated effects on triglyceridaemia only. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:335 / 339
页数:5
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