Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type a and B influenza viruses

被引：41

作者：

Ehrhardt, Christina

Wolff, Thorsten

Ludwig, Stephan

机构：

[1] Univ Munster, Inst Mol Virol, ZMBE, D-48149 Munster, Germany

[2] Robert Koch Inst, D-133533 Berlin, Germany

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 21期

关键词：

D O I：

10.1128/JVI.01216-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K). This function of the protein is likely to prevent premature apoptosis induction during viral propagation. Here we show that the B/NS1 protein completely lacks the capacity to induce PI3K signaling. Thus, PI3K activation is another unique function of A/NS1 that is different from the action of its influenza B virus counterpart.

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页码：12097 / 12100

页数：4

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