Selective cancer cell killing by α-tocopheryl succinate

被引：216

作者：

Neuzil, J ^{[1
]}

Weber, T ^{[1
]}

Gellert, N ^{[1
]}

Weber, C ^{[1
]}

机构：

[1] Univ Munich, Inst Prevent Cardiovasc Dis, D-80336 Munich, Germany

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 01期

关键词：

vitamin E analogue; malignant cells; apoptosis; selectivity;

D O I：

10.1054/bjoc.2000.1559

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report that alpha -tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties. selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and nontransformed cells. These findings strongly suggest a potential of this micronutrient in the therapy and/or prevention of cancer without significant side-effects. (C) 2001 Cancer Research Campaign http://www.bjcancer.com.

引用

页码：87 / 89

页数：3

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