The Experimental Design Assistant

被引：67

作者：

du Sert, Nathalie Percie ^{[1
]}

Bamsey, Ian ^{[2
]}

Bate, Simon T. ^{[3
]}

Berdoy, Manuel ^{[4
]}

Clark, Robin A. ^{[5
]}

Cuthill, Innes ^{[6
]}

Fry, Derek ^{[7
]}

Karp, Natasha A. ^{[8
,9
]}

Macleod, Malcolm ^{[10
]}

Moon, Lawrence ^{[11
]}

Stanford, S. Clare ^{[12
]}

Lings, Brian ^{[2
]}

机构：

[1] Natl Ctr Replacement Refinement & Reduct Anim Res, London, England

[2] Certus Technol Associates Ltd, Exeter, Devon, England

[3] GlaxoSmithKline, Stevenage, Herts, England

[4] Univ Oxford, Oxford, England

[5] Erivigo, Alconbury, England

[6] Univ Bristol, Bristol, Avon, England

[7] Univ Manchester, Manchester, Lancs, England

[8] Wellcome Trust Sanger Inst, Hinxton, England

[9] AstraZeneca R&D, Quantitat Biol IMED, Cambridge, England

[10] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[11] Kings Coll London, London, England

[12] UCL, London, England

来源：

PLOS BIOLOGY | 2017年 / 15卷 / 09期

关键词：

REPRODUCIBILITY; NEUROSCIENCE; POWER;

D O I：

10.1371/journal.pbio.2003779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Addressing the common problems that researchers encounter when designing and analysing animal experiments will improve the reliability of in vivo research. In this article, the Experimental Design Assistant (EDA) is introduced. The EDA is a web-based tool that guides the in vivo researcher through the experimental design and analysis process, providing automated feedback on the proposed design and generating a graphical summary that aids communication with colleagues, funders, regulatory authorities, and the wider scientific community. It will have an important role in addressing causes of irreproducibility.

引用

页数：9

共 21 条

[1]

[Anonymous], 2014, DESIGN STAT ANAL ANI

[2]

Reproducibility in Science Improving the Standard for Basic and Preclinical Research [J].

Begley, C. Glenn ;

Ioannidis, John P. A. .

CIRCULATION RESEARCH, 2015, 116 (01) :116-126

[3]

Raise standards for preclinical cancer research [J].

Begley, C. Glenn ;

Ellis, Lee M. .

NATURE, 2012, 483 (7391) :531-533

[4]

Power failure: why small sample size undermines the reliability of neuroscience [J].

Button, Katherine S. ;

Ioannidis, John P. A. ;

Mokrysz, Claire ;

Nosek, Brian A. ;

Flint, Jonathan ;

Robinson, Emma S. J. ;

Munafo, Marcus R. .

NATURE REVIEWS NEUROSCIENCE, 2013, 14 (05) :365-376

[5]

Cressey D., 2016, NATURE, V531

[6]

Cressey Daniel, 2016, NATURE

[7]

du Sert N Percie, 2017, NAT METHODS

[8]

Randomized Block Experimental Designs Can Increase the Power and Reproducibility of Laboratory Animal Experiments [J].

Festing, Michael F. W. .

ILAR JOURNAL, 2014, 55 (03) :472-476

[9]

The Economics of Reproducibility in Preclinical Research [J].

Freedman, Leonard P. ;

Cockburn, Iain M. ;

Simcoe, Timothy S. .

PLOS BIOLOGY, 2015, 13 (06) :1-9

[10]

What does research reproducibility mean? [J].

Goodman, Steven N. ;

Fanelli, Daniele ;

Ioannidis, John P. A. .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (341)

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