Poly(ε-caprolactone) reinforced with sol-gel synthesized organic-inorganic hybrid fillers as composite substrates for tissue engineering

被引：59

作者：

Russo, Teresa ^{[2
]}

Gloria, Antonio ^{[1
]}

D'Anto, Vincenzo ^{[3
]}

D'Amora, Ugo ^{[1
]}

Ametrano, Gianluca ^{[3
]}

Bollino, Flavia ^{[4
]}

De Santis, Roberto ^{[1
]}

Ausanio, Giovanni ^{[5
]}

Catauro, Michelina ^{[4
]}

Rengo, Sandro ^{[3
]}

Ambrosio, Luigi ^{[1
]}

机构：

[1] CNR, Inst Composite & Biomed Mat, IT-80125 Naples, Italy

[2] Univ Naples Federico II, Dept Mat & Prod Engn, Naples, Italy

[3] Univ Naples Federico II, Dept Oral & Maxillofacial Sci, Naples, Italy

[4] Univ Naples 2, Dept Mech & Aerosp Engn, Aversa, Italy

[5] Univ Naples Federico II, Dept Physiol, CNR, SPIN, Naples, Italy

来源：

JOURNAL OF APPLIED BIOMATERIALS & BIOMECHANICS | 2010年 / 8卷 / 03期

关键词：

Alamar Blue (TM) assay; Atomic force microscopy; Composite substrate; Organic-inorganic hybrid; Poly(epsilon-caprolactone); Small punch test; MECHANICAL-PROPERTIES; SCAFFOLDS; GLASSES; PROTEIN; BIOACTIVITY; OXIDE); ROUTES; ASSAY;

D O I：

10.5301/JABB.2010.6094

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Purpose: The importance of polymer-based composite materials to make multifunctional substrates for tissue engineering and the strategies to improve their performances have been stressed in the literature. Bioactive features of sol-gel synthesized poly(epsilon-caprolactone)/TiO2 or poly(epsilon-caprolactone)/ZrO2 organic-inorganic hybrid materials are widely documented. Accordingly, the aim of this preliminary research was to develop advanced composite substrates consisting of a poly(epsilon-caprolactone) matrix reinforced with sol-gel synthesized PCL/TiO2 or PCL/ZrO2 hybrid fillers. Methods: Micro-computed tomography and atomic force microscopy analyses allowed to study surface topography and roughness. On the other hand, mechanical and biological performances were evaluated by small punch tests and Alamar Blue (TM) assay, respectively. Results: Micro-computed tomography and atomic force microscopy analyses highlighted the effect of the preparation technique. Results from small punch tests and Alamar Blue (TM) assay evidenced that PCL reinforced with Ti2 (PCL=12, TiO2 = 88 wt%) and Zr2 (PCL=12, ZrO2 = 88 wt%) hybrid fillers provided better mechanical and biological performances. Conclusions: PCL reinforced with Ti2 (PCL=12, TiO2 = 88 wt%) and Zr2 (PCL=12, ZrO2 = 88 wt%) hybrid fillers could be considered as advanced composite substrates for hard tissue engineering.

引用

页码：146 / 152

页数：7

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