Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis

被引:16
作者
Alonso, Nuria [1 ,5 ]
Granada, Maria Luisa [2 ,5 ]
Salinas, Isabel [1 ,5 ]
Reverter, Jorge Luis [1 ,5 ]
Flores, Lilliam [1 ,5 ]
Ojanguren, Isabel [3 ,5 ]
Martinez-Caceres, Eva Maria [4 ,5 ]
Sanmarti, Anna [1 ,5 ]
机构
[1] Hosp Univ Germans Trias Pujol, Dept Endocrinol & Nutr, Barcelona 08916, Spain
[2] Univ Autonoma Barcelona, Hosp Univ Germans Trias Pujol, Dept Clin Biochem, Barcelona, Spain
[3] Hosp Univ Germans Trias Pujol, Dept Pathol, Barcelona, Spain
[4] Hosp Univ Germans Trias Pujol, Dept Immunol, LIRAD BST, Barcelona, Spain
[5] Univ Autonoma Barcelona, Hosp Univ Germans Trias Pujol, Dept Med, Barcelona, Spain
关键词
D O I
10.1530/EJE-07-0300
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Objective: Type 1 diabetes mellitus patients (DM1) show increased prevalence of pernicious anaemia, the histological substrate of which is type A chronic atrophic gastritis (CAG) in the stomach corpus, the main source of ghrelin. We aimed to compare plasma ghrelin concentrations in DM1 patients with type A CAG (DM1-CAG), DM1 patients without type A CAG and healthy controls and in DM1-CAG group, to ascertain a possible relationship between ghrelin and biochemical markers of gastric mucosa atrophy and/or neuroendocrine (NE) cell hyperplasia and histological gastric biopsy findings. Design and methods: Fifteen DM1-CAG patients were matched for age, sex and body mass index with 15 DM1. patients without type A CAG and 15 controls. Pepsinogen I, pepsinogen II, gastrin, parietal cell antibodies, chromogranin A (CgA) and ghrelin were determined in all subjects. In DM1-CAG patients, immunohistochemical analysis of gastric biopsies using antibodies to CgA and ghrelin was performed. Results: Ghrelin concentrations differed among groups; however, paired comparisons between groups were not significant. In DM1-CAG, no correlation was found between ghrelin and gastric body atrophy markers, pepsinogen I and the pepsinogen I/II ratio. Immunohistochemical studies of DM1-CAG patients showed CgA staining in 12 and ghrelin staining in 6, which was confined to the foci of NE cell hyperplasia. Those patients who stained positive for ghrelin had higher ghrelin concentrations when compared with the negative patients. Conclusions: Ghrelin concentrations are not decreased in DM1-CAG patients; thus, our data suggest that ghrelin is not a good marker of gastric mucosa atrophy in these patients, given the possible ghrelin synthesis in hyperplastic gastric endocrine/enterochromaffin-like cells.
引用
收藏
页码:763 / 769
页数:7
相关论文
共 31 条
[1]
Serum pepsinogen I:: An early marker of pernicious anemia in patients with type 1 diabetes [J].
Alonso, N ;
Granada, ML ;
Salinas, I ;
Lucas, AM ;
Reverter, JL ;
Juncà, J ;
Oriol, A ;
Sanmartí, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (09) :5254-5258
[2]
BEDICI A, 2005, J PEDIATR ENDOCR MET, V18, P1433
[3]
Circulating acylated and total ghrelin and galanin in children with insulin-treated type 1 diabetes: relationship to insulin therapy, metabolic control and pubertal development [J].
Celi, F ;
Bini, V ;
Papi, F ;
Santilli, E ;
Ferretti, A ;
Mencacci, M ;
Berioli, MG ;
De Giorgi, G ;
Falorni, A .
CLINICAL ENDOCRINOLOGY, 2005, 63 (02) :139-145
[4]
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: Identification of one pancreatic ghrelinoma [J].
Corbetta, S ;
Peracchi, M ;
Cappiello, V ;
Lania, A ;
Lauri, E ;
Vago, L ;
Beck-Peccoz, P ;
Spada, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (07) :3117-3120
[5]
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans [J].
Date, Y ;
Kojima, M ;
Hosoda, H ;
Sawaguchi, A ;
Mondal, MS ;
Suganuma, T ;
Matsukura, S ;
Kangawa, K ;
Nakazato, M .
ENDOCRINOLOGY, 2000, 141 (11) :4255-4261
[6]
Neuroendocrine tumor markers and enterochromaffin-like cell hyper/dysplasia in type 1 diabetes [J].
De Block, CEM ;
Colpin, G ;
Thielemans, K ;
Coopmans, W ;
Bogers, JJPM ;
Pelckmans, PA ;
Van Marck, EAE ;
Van Hoof, V ;
Martin, M ;
De Leeuw, IH ;
Bouillon, R ;
Van Gaal, LF .
DIABETES CARE, 2004, 27 (06) :1387-1393
[7]
A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control [J].
de la Cour, CD ;
Björkqvist, M ;
Sandvik, AK ;
Bakke, I ;
Zhao, CM ;
Chen, D ;
Håkanson, R .
REGULATORY PEPTIDES, 2001, 99 (2-3) :141-150
[8]
Classification and grading of gastritis - The updated Sydney System [J].
Dixon, MF ;
Genta, RM ;
Yardley, JH ;
Correa, P ;
Batts, KP ;
Dahms, BB ;
Filipe, MI ;
Haggitt, RC ;
Haot, J ;
Hui, PK ;
Lechago, J ;
Lewin, K ;
Offerhaus, JA ;
Price, AB ;
Riddell, RH ;
Sipponen, P ;
Solcia, E ;
Watanabe, H .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (10) :1161-1181
[9]
Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor [J].
Ghigo, E ;
Broglio, F ;
Arvat, E ;
Maccario, M ;
Papotti, M ;
Muccioli, G .
CLINICAL ENDOCRINOLOGY, 2005, 62 (01) :1-17
[10]
Low plasma ghrelin levels in patients with Helicobacter pylori -: Associated gastritis [J].
Isomoto, H ;
Nakazato, M ;
Ueno, H ;
Date, Y ;
Nishi, Y ;
Mukae, H ;
Mizuta, Y ;
Ohtsuru, A ;
Yamashita, S ;
Kohno, S .
AMERICAN JOURNAL OF MEDICINE, 2004, 117 (06) :429-432