Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia

被引：155

作者：

Chu, K

Kim, M

Jeong, SW

Kim, SU

Yoon, BW ^{[1
]}

机构：

[1] Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea

[2] Seoul Natl Univ Hosp, Clin Res Inst, Seoul, South Korea

[3] SNUMRC, Neurosci Res Inst, Seoul, South Korea

[4] Ajou Univ, Brain Dis Res Ctr, Suwon 441749, South Korea

[5] Univ British Columbia, UBC Hosp, Dept Med, Div Neurol, Vancouver, BC V5Z 1M9, Canada

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 02期

关键词：

global ischemia; rat; human neural stem cell; transplantation; intravenous; chimera; migration; differentiation; radial glia; hippocampus;

D O I：

10.1016/S0304-3940(03)00174-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraparenchymally transplanted rodent-origin neural and human-origin mesenchymal stem cells migrate and differentiate in neurological diseases. By intravenously injecting human neural stem cells, we showed that transplanted human neural stem cells migrate to the damaged hippocampus, proliferate and differentiate into mature neurons and astrocytes in the adult rat brain with transient forebrain ischemia. We also demonstrated the migratory course of implanted human neural stem cells after intravenous injection. Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：129 / 133

页数：5

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