CRP after 2004

被引：81

作者：

Agrawal, A ^{[1
]}

机构：

[1] E Tennessee State Univ, Dept Pharmacol, Johnson City, TN 37614 USA

来源：

MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 08期

关键词：

C-reactive protein; complement; phosphocholine; atherosclerosis;

D O I：

10.1016/j.molimm.2004.09.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-reactive protein (CRP) that has been conserved throughout evolution is a host-defense molecule. Its attraction towards phosphocholine-ligands, such as modified low-density lipoprotein, and apoptotic cells leads to the "masking" of these substances that have the capabilities to otherwise engage in deleterious activities. Complement activation by CRP complexes and the modulation by CRP of complement activation by its ligands add up to its beneficial effects. In the presence of CRP, production of membrane-damaging last product of the complement pathway is arrested. CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：927 / 930

页数：4

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