Gender-related differences in apoptotic pathways after neonatal cerebral ischemia

被引：86

作者：

Renolleau, Sylvain ^{[1
,2
]}

Fau, Sebastien ^{[1
,2
]}

Charriaut-Marlangue, Christiane ^{[1
]}

机构：

[1] Univ Paris 06, F-75252 Paris 05, France

[2] Univ Paris 06, Hop Armand Trousseau, Serv Reanimat Neonatale & Pediat, F-75252 Paris 05, France

来源：

NEUROSCIENTIST | 2008年 / 14卷 / 01期

关键词：

female; male; caspase inhibitor; mitochondria; cytochrome c; cell death; TRAUMATIC BRAIN INJURY; Q-VD-OPH; HYPOXIA-ISCHEMIA; CELL-DEATH; RAT-BRAIN; CASPASE-3; ACTIVATION; NITRIC-OXIDE; POLY(ADP-RIBOSE) POLYMERASE; NUCLEAR TRANSLOCATION; MITOCHONDRIAL PATHWAY;

D O I：

10.1177/1073858407308889

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Many central nervous system (CNS) diseases display sexual dimorphism, specifically a predilection for one gender or a gender-dependent response to treatment. Exposure to circulating sex steroids is felt to be a chief contributor to this phenomenon. However, CNS diseases of childhood and of the elderly also demonstrate gender predominance and/or sexual dimorphism response to therapies. In this short update, we provide information concerning one of the most interesting new emerging concepts related to the influence of the sex in the pathogenesis of developmental brain injuries leading to different levels of neuroprotection between genders after cerebral hypoxia-ischemia or ischemia.

引用

页码：46 / 52

页数：7

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