Novel 5,5-disubstitutedpyrimidine-2,4,6-trione as selective MMP inhibitors

被引：40

作者：

Foley, LH ^{[1
]}

Palermo, R ^{[1
]}

Dunten, P ^{[1
]}

Wang, P ^{[1
]}

机构：

[1] Hoffmann La Roche Inc, Roche Res Ctr, Nutley, NJ 07110 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00104-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 5.5-disubstitutedpyrimidine-2,4.6-trione represent a new class of MIL IP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：969 / 972

页数：4

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