Use of metformin in pediatric age

被引：27

作者：

Brufani, Claudia ^{[1
]}

Fintini, Danilo ^{[2
]}

Nobili, Valerio ^{[3
]}

Patera, Patrizia Ippolita ^{[1
]}

Cappa, Marco ^{[1
]}

Brufani, Mario ^{[4
]}

机构：

[1] Bambino Gesu Pediat Hosp, Endocrinol & Diabet Unit, IRCCS, I-00165 Rome, Italy

[2] Bambino Gesu Pediat Hosp, Cardio Resp & Sport Med Unit, IRCCS, I-00165 Rome, Italy

[3] Bambino Gesu Pediat Hosp, Liver Unit, IRCCS, I-00165 Rome, Italy

[4] Univ Roma La Sapienza, Biochem Dept Rossi Fanelli, Rome, Italy

来源：

PEDIATRIC DIABETES | 2011年 / 12卷 / 06期

关键词：

ALT; AMPK; BMI children; GI; HbA1c; HOMA-IR; metformin; NAFLD; NASH; obesity; OCs; PCOS; T2DM; POLYCYSTIC-OVARY-SYNDROME; ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE; LOW-DOSE FLUTAMIDE; PLACEBO-CONTROLLED TRIAL; LIFE-STYLE INTERVENTION; BODY-MASS INDEX; OBESE ADOLESCENTS; GLUCOSE-TOLERANCE; WEIGHT-GAIN;

D O I：

10.1111/j.1399-5448.2010.00741.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Metformin is currently the most widely used drug worldwide for the treatment of type 2 diabetes (T2DM) in adults. Its primary action appears to be the inhibition of hepatic glucose production and the increase in peripheral insulin sensitivity (1). Due to the worldwide increase of pediatric obesity and its related complications (2-4), the adoption of treatment with metformin has significantly increased in children and adolescents. Whereas only short-term data are available on the benefits of metformin in obese children and adolescents with insulin resistance and normal glucose tolerance (5), metformin therapy in adolescents affected by T2DM is well established (6). Metformin is also beneficial in girls with polycystic ovarian syndrome (PCOS) (7). Moreover, the use of metformin has been recently extended to other conditions with promising results (8-10). This review summarizes scientific evidences and practical considerations for the use of metformin in the treatment of different diseases affecting children and adolescents.

引用

页码：580 / 588

页数：9

共 58 条

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