Pharmacotherapy of overactive bladder: epidemiology and pathophysiology of overactive bladder

被引：27

作者：

Latini, Jerilyn M. ^{[1
]}

Giannantoni, Antonella ^{[2
]}

机构：

[1] Univ Michigan, Dept Urol, Taubman Ctr 3875, Ann Arbor, MI 48109 USA

[2] Univ Perugia, Dept Urol, Osped Santa Maria Misericordia, I-06100 Perugia, Italy

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2011年 / 12卷 / 07期

关键词：

URINARY-TRACT SYMPTOMS; NERVE GROWTH-FACTOR; QUALITY-OF-LIFE; LUMBOSACRAL SPINAL-CORD; INTRAVESICAL CAPSAICIN; INCREASED EXPRESSION; AFFERENT ACTIVITY; PREVALENCE; INCONTINENCE; WOMEN;

D O I：

10.1517/14656566.2011.554396

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Areas covered: The epidemiology and pathophysiology of OAB is reviewed. A literature search using PubMed from 2000 to 2010 was undertaken for this review with pertinent older papers referenced as needed to gain a clearer understanding of the epidemiology of OAB and related bladder pathophysiology, which it is hoped will lead to more effective and better-tolerated treatments for OAB. Expert opinion: With recent advances in our understanding of the basic science of OAB, it is becoming clear that the control of bladder function is far more complex than previously believed. Recent research has highlighted several potential targets for the treatment of OAB, particularly within the mechanosensory pathways.

引用

页码：1017 / 1027

页数：11

共 82 条

[1]

Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052

[2]

Abrams Paul, 2009, Neurourol Urodyn, V28, P287, DOI 10.1002/nau.20737

[3]

Antimuscarinics for treatment of overactive bladder [J].

Andersson, KE .

LANCET NEUROLOGY, 2004, 3 (01) :46-53

[4]

The use of botulinum neurotoxin type A (BoNTA) in urology [J].

Apostolidis, A. ;

Fowler, C. J. .

JOURNAL OF NEURAL TRANSMISSION, 2008, 115 (04) :593-605

[5]

Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity [J].

Apostolidis, A ;

Popat, R ;

Yiangou, Y ;

Cockayne, D ;

Ford, APDW ;

Davis, JB ;

Dasgupta, P ;

Fowler, CJ ;

Anand, P .

JOURNAL OF UROLOGY, 2005, 174 (03) :977-982

[6]

Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction [J].

Araki, I ;

Du, SQ ;

Kamiyama, M ;

Mikami, Y ;

Matsushita, K ;

Komuro, N ;

Furuya, Y ;

Takeda, M .

UROLOGY, 2004, 64 (06) :1255-1260

[7]

Benner, Joshua S. ;

Becker, Russell ;

Fanning, Kristina ;

Jumadilova, Zhanna ;

Bavendam, Tamara ;

Brubaker, Linda .

JOURNAL OF UROLOGY, 2009, 181 (06) :2591-2598

[8]

Estrogen receptor expression in lumbosacral dorsal root ganglion cells innervating the female rat urinary bladder [J].

Bennett, HL ;

Gustafsson, JÅ ;

Keast, JR .

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2003, 105 (02) :90-100

[9]

P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin [J].

Brady, CM ;

Apostolidis, A ;

Yiangou, Y ;

Baecker, PA ;

Ford, AP ;

Freeman, A ;

Jacques, TS ;

Fowler, CJ ;

Anand, P .

EUROPEAN UROLOGY, 2004, 46 (02) :247-253

[10]

Effect of an ATP-sensitive potassium channel opener in subjects with overactive bladder: A randomized, double-blind, placebo-controlled study (ZD0947IL/0004) [J].

Chapple, CR ;

Patroneva, A ;

Raines, SR .

EUROPEAN UROLOGY, 2006, 49 (05) :879-886

← 1 2 3 4 5 6 7 8 9 →