rhinovirus;
common cold;
interleukin-8;
viral respiratory infection;
free radicals;
D O I:
10.1016/S0891-5849(98)00233-0
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
A direct correlation has been reported between the severity of symptoms associated with rhinovirus infection and the concentration of interleukin-8 in nasal secretions. The purpose of these studies was to examine the mechanism of rhinovirus-induced IL-8 elaboration. Rhinovinrs infection induced oxidative stress in Beas-2b cells and the concentration of H2O2 in supernatant media from rhinovirus challenged cells was 12.5 +/- 6.1 mu M 1 h after challenge compared to 0.7 +/- 0.3 mu M in supernatant from control cells. N-acetyl cysteine inhibited RV-induced NF-kappa B activation and IL-8 elaboration IL-8 concentrations were 36 +/- 2 pg/ml and 10 +/- 1 pg/ml 6 h after virus challenge in untreated and NAG-treated (30 mM NAC) cells, respectively. Despite the effects of NAC on IL-8 elaboration and NF-kappa B activation, RV stimulated increases in supernatant H2O2 were not altered by NAG. These data suggest that RV stimulation of IL-8 in respiratory epithelium is mediated through production of oxidative species and the subsequent activation of NF-kappa B. (C) 1998 Elsevier Science Inc.
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
DEFORGE, LE
FANTONE, JC
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机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
FANTONE, JC
KENNEY, JS
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
KENNEY, JS
REMICK, DG
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
DEFORGE, LE
FANTONE, JC
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
FANTONE, JC
KENNEY, JS
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA
KENNEY, JS
REMICK, DG
论文数: 0引用数: 0
h-index: 0
机构:
UNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USAUNIV MICHIGAN, SCH MED, DEPT PATHOL, M2210 MED SCI 1, ANN ARBOR, MI 48109 USA