Streptokinase - a clinically useful thrombolytic agent

被引：139

作者：

Banerjee, A

Chisti, Y

Banerjee, UC

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Mohali 160062, Punjab, India

[2] Massey Univ, Inst Technol & Engn, Palmerston North, New Zealand

来源：

BIOTECHNOLOGY ADVANCES | 2004年 / 22卷 / 04期

关键词：

streptokinase; staphylokinase; urokinase; tissue type plasminogen activator; thrombolytic agents; fibrinolysis;

D O I：

10.1016/j.biotechadv.2003.09.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A failure of hemostasis and consequent formation of blood clots in the circulatory system can produce severe outcomes such as stroke and myocardial infraction. Pathological development of blood clots requires clinical intervention with fibrinolytic agents such as urokinase, tissue plasminogen activator and streptokinase. This review deals with streptokinase as a clinically important and cost-effective plasminogen activator. The aspects discussed include: the mode of action; the structure and structure-function relationships; the structural modifications for improving functionality; recombinant streptokinase; microbial production; and recovery of this protein from crude broths. (C) 2003 Published by Elsevier Inc.

引用

页码：287 / 307

页数：21

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