Synthesis of NPS R-568 utilizing titanium-catalyzed asymmetric hydrosilylation

被引:22
作者
Hansen, MC [1 ]
Buchwald, SL [1 ]
机构
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S0040-4039(99)00085-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The enantioselective hydrosilylation of imines catalyzed by an (EBTHI) Ti (EBTHI=ethylene-bis(eta(5)-tetrahydroindenyl)) species was applied to the synthesis of NPS R-568, an active compound for the treatment of hyperparathyroidism. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2033 / 2034
页数:2
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