Preparation of purpurin-18 loaded magnetic nanocarriers in cottonseed oil for photodynamic therapy

被引：26

作者：

Liu, Fuxian ^{[1
]}

Zhou, Xingping ^{[1
]}

Chen, Zhilong ^{[1
]}

Huang, Peng ^{[1
]}

Wang, Xiaqin ^{[2
]}

Zhou, Yong ^{[3
]}

机构：

[1] Donghua Univ, Inst Biol Sci & Biotechnol, Shanghai 201620, Peoples R China

[2] Donghua Univ, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China

[3] Natl Inst Adv Ind Sci & Technol, Nanoarchitecton Res Ctr, Tsukuba, Ibaraki 3058565, Japan

来源：

MATERIALS LETTERS | 2008年 / 62卷 / 17-18期

关键词：

purpurin-18; magnetic nanocarriers; single oxygen; micro-emulsion;

D O I：

10.1016/j.matlet.2008.01.123

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Purpurin-18 loaded magnetic silica nanocarriers for photodynamic therapy (PDT) were prepared in cottonseed oil by W/O micro-emulsion method. The size of the nanocarriers was ranged from 20 to 30 nm obtained from transmission electron micrograph observation. The photodynamic drug purpurin-18 was successfully enwrapped in the nanocarriers characterized by ultraviolet-visible absorption and Fourier transforrn infrared spectroscopy spectra. The generation of singlet oxygen (O-1(2)) was followed by N,N-dimethyl-4-nitrosoaniline (RNO) bleaching assay. The loss of RNO absorbance at 440 nm versus irradiation time displayed that purpurin-18 could play a role in normal. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：2844 / 2847

页数：4

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