Comparative activities of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemases

被引：82

作者：

Tripodi, Marie-Francoise ^{[1
,2
]}

Durante-Mangoni, Emanuele ^{[1
,3
]}

Fortunato, Rosaria ^{[1
,2
]}

Utili, Riccardo ^{[1
,3
]}

Zarrilli, Raffaele ^{[4
,5
]}

机构：

[1] Univ Naples 2, Chair Internal Med, Naples, Italy

[2] Univ Naples 2, Div Internal Med & Hepatol, Naples, Italy

[3] Univ Naples 2, Unit Infect & Transplant Med, Naples, Italy

[4] Univ Naples Federico II, Hygiene Sect, Dept Prevent Med Sci, Naples, Italy

[5] CEINGE Adv Biotechnol, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2007年 / 30卷 / 06期

关键词：

Acinetobacter; OXA-58; carbapenemase; time-kill assay; colistin; rifampicin;

D O I：

10.1016/j.ijantimicag.2007.07.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. The isolates were susceptible to colistin but differed in their resistance to imipenem and rifampicin. Time-kill studies showed a bactericidal effect for colistin but not for imipenem, rifampicin or sulbactam/ampicillin used as single agents. Synergism was observed with combinations of rifampicin + imipenem or sulbactam/ampicillin for all isolates and with colistin + rifampicin for isolates showing higher minimum inhibitory concentrations for rifampicin. Combined use of the antimicrobials tested may provide good therapeutic options for OXA-58 carbapenemase-producing A. baumannii infections. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：537 / 540

页数：4

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