Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets

被引:94
作者
Prakash, S
Caldwell, JC
Eberl, DF
Clandinin, TR
机构
[1] Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA
[2] Univ Iowa, Dept Biol Sci, Iowa City, IA 52242 USA
关键词
D O I
10.1038/nn1415
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Classical cadherins have been proposed to mediate interactions between pre- and postsynaptic cells that are necessary for synapse formation. We provide the first direct, genetic evidence in favor of this model by examining the role of N-cadherin in controlling the pattern of synaptic connections made by photoreceptor axons in Drosophila. N-cadherin is required in both individual photoreceptors and their target neurons for photoreceptor axon extension. Cell-by-cell reconstruction of wild-type photoreceptor axons extending within mosaic patches of mutant target cells shows that N-cadherin mediates attractive interactions between photoreceptors and their targets. This interaction is not limited to those cells that will become the synaptic partners of photoreceptors. Multiple N-cadherin isoforms are produced, but single isoforms can substitute for endogenous N-cadherin activity. We propose that N-cadherin mediates a homophilic, attractive interaction between photoreceptor growth cones and their targets that precedes synaptic partner choice.
引用
收藏
页码:443 / 450
页数:8
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