Antihistamines and production of granulocyte-macrophage colony-stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro: Evaluation of the effects of loratadine and cetirizine

被引：6

作者：

Amsellem, C

Gormand, F

Hosni, R

Aloui, R

Guibert, B

Czarlewski, W

Melac, M

Lagarde, M

PerrinFayolle, M

Pacheco, Y

机构：

[1] CTR HOSP LYON SUD, SERV PNEUMOL, LAB IMMUNOALLERGOL RESP, F-69310 PIERRE BENITE, FRANCE

[2] LAB SCHERING PLOUGH, LEVALLOIS PERRET, FRANCE

[3] LAB UCB PHARMA, NANTERRE, FRANCE

[4] INSA, CHIM BIOL LAB, INSERM U352, VILLEURBANNE, FRANCE

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1996年 / 27卷 / 02期

关键词：

allergy; asthma; bronchial epithelial cells; cetirizine; granulocyte-macrophage colony-stimulating factor; interleukin-8; loratadine;

D O I：

10.1016/0306-3623(95)02009-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. In this study, we compared the effects of two antihistamine drugs on the production of granulocyte macrophage colony stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro. 2. Cytokine production was assessed by the use of an enzyme linked immunosorbent assay. 3. Epithelial cells spontaneously released both cytokines and tumor necrosis factor alone induced a significant increase in this production but loratadine and cetirizine had no effect at the various concentrations studied. 4. The antihistamines have no effect and this suggests that histamine plays no role in cytokine production under these conditions.

引用

页码：269 / 272

页数：4

共 28 条

[1] IN-VITRO INHIBITION, BY LORATADINE AND DESCARBOXYETHOXYLORATADINE, OF HISTAMINE-RELEASE FROM HUMAN BASOPHILS, AND OF HISTAMINE-RELEASE AND INTRACELLULAR CALCIUM FLUXES IN RAT BASOPHILIC LEUKEMIA-CELLS (RBL-2H3) [J].